NCN® Hurdle Nanoclusters

Next-Generation high-performance products

Fighting bacterial and viral infections is one of the most important applications of nanomedicine; NCN® Hurdle Nanoclusters with well-defined ultra-small size and tunable surface chemistry, and they are emerging as next-generation high-performance antibacterial and antiviral products.

NCN® Hurdle Nanoclusters can more easily penetrate the bacterial cell envelope than conventional nanomaterials due to their ultra-small size. Meanwhile, the abundant active sites of NCN® Hurdle Nanoclusters help catalyze bacterial/virus intracellular biochemical processes, resulting in improved antibacterial and antiviral properties.

The inherent advantages of the structure of NCN® Hurdle Nanoclusters are the large surface area, precise dimensions, morphology control, ease of surface modification, and physicochemical properties, such as unique optical, electromagnetic, and catalytic properties; this allows NCN® Hurdle Nanoclusters to have precisely adjustable antibacterial and antiviral activity.

The general mechanisms of NCN® Hurdle Nanoclusters targeted bacterial and viral infections include cell wall and/or membrane damage, metal ions release, intracellular ROS generation, destruction of intracellular components, the delivery of therapeutic agents, and photoactivated mechanisms.

The physico-chemical properties of NCN® Hurdle Nanoclusters, including size, composition, oxidation state, and surface chemistry, govern their antibacterial and antiviral behaviors. NCN® Hurdle Nanoclusters can be integrated with other therapeutic or functional materials, such as antimicrobial peptides, 2D nanomaterials, and polymers, to form complementary nanohybrids with synergistically enhanced antibacterial effects.

Based on the regulation of the physico-chemical properties of the NCN® Hurdle Nanoclusters and further functionalization, the multifarious personalized antibacterial nanomaterials can be fabricated for precision nanomedicine.

Currently, NCN® Hurdle Nanoclusters are used effectively for the antibacterial treatment of fabrics for hospital use (sheets), medical devices for respiratory protection (mask) and for the treatment/construction of antibacterial/antiviral filter media for indoor air purification (media air filter).