NCN® Drug Delivery Nanoclusters

Solving major problems in drug delivery

How do we efficiently get the therapeutic agent into the cell?

Nite Technology is pioneering the use of nanoclusters cell membrane coated to increase the intracellular delivery efficiency of therapeutic agents, improving effectiveness, and decreasing side effects. By utilizing engineered cell membranes that express viral fusion proteins to attach to the cell of interest, dramatically improved endosomal escape and increased expression of mRNA can be achieved.

NCN® nanoclusters are synthesized as nanocarriers for drug delivery, a spontaneous process that relies on the specific binding between the drug molecule and the NCN nanoclusters.
The NCN® loaded with a suitable pharmacological molecule show an antimicrobial activity comparable with the original pharmacological molecule and the number of molecules released by the NCN® is proportional to the quantity of bacteria present. The controlled nature of the release of drug molecules is very encouraging and promising for nanomedicine applications.

How do we target the desired tissue types?

The basis of the NCN technology is the complete adaptability to the most diverse cell membranes and this peculiarity can be used to create specific NCNs for the specific application.
By exploiting specific cells, we can use specific NCN® to target tissues of interest. Through better targeting, NCN® improve therapeutic efficacy, reduce drug burden, and reduce side effects.
NCN® Nanoclusters coated with macrophage membranes simulate the function of macrophages of origin and simultaneously neutralize multiple proinflammatory factors, including lipopolysaccharide (LPS) and inflammatory cytokines.

Furthermore, membrane coated NCN® Nanoclusters of CD4+ T cells or lung epithelial cells exhibit the same protein receptors, both identified and unidentified, required by viruses for cell entry.
By acting as source cell decoys to intercept and block viral entry, these nanoparticles effectively inhibited the infectivity of critical viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus showing great potential as a novel antiviral therapy.